In a remarkable leap forward for vision science, the Limnopharma team has recently unveiled groundbreaking research in the fight against retinitis pigmentosa, a leading cause of inherited blindness. This achievement not only shines a light on new therapeutic avenues but also brings hope to millions affected by this debilitating condition.

Retinitis pigmentosa is a common cause of inherited blindness in adults, which in many cases is associated with an increase in the formation of reactive oxygen species (ROS) that induces DNA damage. This attack triggers a cascade of cellular events leading to the death of photoreceptor cells, the very cells critical for capturing visual information. At the heart of this process is an enzyme known as Poly-ADP-Ribose Polymerase 1 (PARP1), whose overactivation spells disaster for these vital cells.

Building on previous findings that highlighted the potential of resveratrol (RSV) to counteract PARP1’s harmful overactivity, our team tackled RSV’s major flaw—its low bioavailability, which has hampered its medical application. PIC-OCT not only surpasses RSV in its ability to reach the cells that need it most but also boasts an improved profile for absorption, distribution, metabolism, and excretion (ADME).

Our research revealed that when cells under oxidative stress from hydrogen peroxide (H2O2) were treated with PIC-OCT, an impressive 38% more cells survived. This resilience is attributed to several factors, including the preservation of crucial cellular balances, suppression of ROS formation, and maintenance of mitochondrial function. Essentially, PIC-OCT arms cells with a shield against oxidative stress, keeping the destructive effects of PARP1 at bay.

At Limnopharma, our commitment is to light the path to a future where retinal degeneration no longer steals the sight of countless individuals. This latest discovery is a significant milestone in our journey. It’s not just a win for science; it’s a beacon of hope for those facing the darkness of retinal degeneration, demonstrating our unwavering dedication to improving lives through innovation.

Stay tuned as we continue to explore the frontiers of eye health, driven by our mission to bring the world into clearer view for everyone.