New therapies for retinal diseases.
Treatments for Age-Related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP)

The company

Limnopharma was created in March 2019 with the aim of developing new therapies for different retina diseases, which affect more than 200 million people worldwide and for which current treatments either do not exist or are extremely expensive and invasive. The diseases initially targeted are Age-Related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP).

The origin of Limnopharma can be charted back to the scientific research carried out by doctors Juan Carlos Morales Sánchez and Francisco Díaz Corrales, at the Spanish National Research Council (“Consejo Superior de Investigaciones Científicas” – “CSIC”) and the Progreso y Salud Foundation (“Fundación Progreso y Salud” – “FPS”, Junta de Andalucía (Regional Government of Andalusia)), respectively. This research enabled the compounds LIM21 and LIM109 to be obtained and validated as an effective treatment in animal models of the diseases. These findings resulted in two patents, the worldwide rights to which are owned exclusively by Limnopharma.

Limnopharma aims to carry out the early stages of the development of potential medications, specifically completing the preclinical phase and clinical phases I and II of our compounds for the different treatments, and then obtain approval to start clinical trials with the drugs.

The team

Juan Carlos Morales Sánchez has a PhD in Chemistry (Autonomous University of Madrid, 1996) and completed his education at the Universities of East Anglia (1991), Alcalá (1992), Sheffield (1995), Rochester (1997-1998), Stanford (1999), Institute of Organic Chemistry (belonging to the Spanish National Research Council, hereinafter “CSIC”) (1993-1996) and Institute of Advanced Chemistry of Catalonia (CSIC) (2000).

He has developed his professional career in the fields of Organic Chemistry and Biological Chemistry in both the public and private sectors. He began his professional career as Head of Chemistry at Puleva Biotech (now BiosearchLife, 2000-2006), resuming academic research at the Spanish National Research Council (CSIC). Juan Carlos is currently a scientific researcher at the López Neyra Institute of Parasitology and Biomedicine (CSIC) in Granada. He is the author of more than 70 publications and 11 patents. His research group focuses on three lines of research: a) design and synthesis of phenolic derivatives with application in inflammatory diseases; b) bioconjugates as tools to study molecular interactions; and c) G-quadruplex DNA ligands as chemotherapy drugs.

After confirming the good results obtained in animal models with the LIM21 and LIM109 molecules, developed within the framework of the scientific work carried out at his laboratory, Juan Carlos decided to launch the project today known as Limno Pharma. Juan Carlos is a founding partner and combines his professional activity with scientific guidance in the company.

Founding Partner and Scientific Advisor

Juan Carlos Morales

jcmorales@limnopharma.com

Francisco graduated in Medicine (MD) from the Los Andes University in Venezuela in 1996 and began his research career studying a new animal model of Parkinson’s disease. He later graduated as a Specialist in Neurology (1998-2002) at the Los Andes University Hospital and worked on the epidemiology of this condition. He then completed a PhD in Medical Sciences (2006) at Okayama University, Japan, which focused on molecular mechanisms and new treatments for Parkinson’s disease.

Francisco moved to Spain after obtaining a grant from the BBVA/ Carolina Foundation, initially to work in clinical and basic research at the Virgen del Rocío Hospital in Seville. Since 2008 he has developed his research at the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) in Seville, where he is a senior scientist and principal researcher on the project.

His current line of research focuses on the neuroprotective effect of different drugs and advanced therapies (cellular and gene therapies) in the treatment of Retinitis Pigmentosa (RP) and Age-Related Macular Degeneration (AMD). He is the author of almost 40 scientific publications, as well as co-inventor of 2 patents. He has extensive experience in clinical research, essential for creating bridges between basic and clinical researchers, and is the scientist responsible for the in vivo experiments in animal models that have driven this initiative.

Founding Partner and Scientific Advisor

Francisco Díaz Corrales

fdiaz@limnopharma.com

David is currently the Executive Director of the Society for the Improvement of Science (“Sociedad para el Avance Científico” – “SACSIS”), which he founded in 2010. SACSIS is an organization created with the aim of promoting scientific research and technological innovation at the highest level. David is also the founder and editor of the family of scientific publications called “The All Results Journals” (ARJ), the first journals on the market dedicated to publishing negative results.

David completed his PhD in Chemistry at the Institute of Chemical Research (Spanish National Research Council (CSIC) – University of Seville), focusing on the synthesis of magnetic nanoparticles with medical applications. He continued his post-doctoral research in Bordeaux and at the Harvard Medical School after obtaining Fulbright and Marie Curie Fellowships scholarships, and pursued his professional career at the Andalusian Nanomedicine and Biotechnology Centre (BIONAND). He has published more than 30 scientific articles and is co-author of 3 patents.

David has an MBA from the EOI Business School (Seville) and a Master in Quality Management (ISO 9001) from UNED (Spanish Open University). He has received several awards for his initiative as an entrepreneur, including the following: Pablo de Olavide University, Best Entrepreneurship Project, 2015; Félix Delgado Bocos Foundation, Best Innovative Approach in Biomedical Science, 2012; Junta de Andalucía (Regional Government of Andalusia), Best Entrepreneurial Initiative for The All Results Journals in 2009; and Bancaja, Best Young Entrepreneur for The All Results Journals, 2008.

Founder

David Alcántara Parra

dalcantara@limnopharma.com

Natalia has a PhD in Organic Chemistry and has a solid background and experience in scientific research. She has developed her career in both academia (Spanish National Research Council (CSIC) and Free University of Berlin, Germany) and the private sector (Abengoa Research).

Natalia’s research over the last 15 years has been highly interdisciplinary, covering areas of Organic and Physical Chemistry, Pharmacology, Microbiology and Biotechnology, focusing in particular on the application of bio-organic chemistry as a tool for understanding biological processes. Her scientific output includes around twenty publications, the co-direction of one doctoral thesis, and as co-author in two patents and different communications at national and international conferences. She has experience in project development, team management and scientific communication.

Natalia has a degree in Chemical Sciences from La Laguna University (2000) and a PhD from the University of Seville (2005). After completing her PhD, she moved to the Free University of Berlin, where she carried out more in-depth research into Nuclear Magnetic Resonance techniques. In 2008 she rejoined the Chemical Research Institute of Seville, where she worked from 2008 until 2014, when she joined the Biotechnology Department of the company Abengoa Research, where she remained until 2017. Since then she has held different R&D consulting posts and has taught as a professor at the University of Seville in the Departments of Physical Chemistry and Analytical Chemistry, at the same time as joining the Limno Pharma team.

Founder

Natalia Pérez Hernández

natalia@limnopharma.com

The Limnopharma Team

Advisory Committee

President of the European Association for the Study of Diabetes (EASD), Eye Complications (EC).

Head of the Diabetes Research and Metabolism Unit.

Research Institute, Vall d’Hebron University Hospital (VHIR).

Dr. Rafael Simó

Director of Pharmaceutical Development at AVIZOREX (AVX).

20 years at Alcon as Director of the Pharmaceutical Development Group in Barcelona.

Expert in specialized technologies for the administration of ophthalmic medications.

Dr. Javier Galán

Emeritus Professor of Ophthalmology at UCL (University College London).

Director of Cabimer from 2008 to 2016.

International expert of recognized prestige in Retinitis Pigmentosa with 275 scientific articles.

Dr. Shomi Bhattacharya

Founder and Medical Director of the Gómez-Ulla Ophthalmological Institute.

Professor of Ophthalmology at Santiago de Compostela University (USC), Spain, and Head of the Ophthalmology Service at Santiago de Compostela University Clinical Hospital (CHUS).

More than 40 years of experience in the treatment of retinal detachment, AMD and diabetic retinopathy, among other diseases.

Dr. Francisco Gómez-Ulla

The future

Limnopharma

Limnopharma is currently focusing on the development and validation of therapies for ophthalmic diseases. This has been possible thanks to the potential demonstrated by the LIM21 and LIM109 molecules, as well as other specific structurally-related compounds, in animal models of Age-Related Macular Degeneration and Retinitis Pigmentosa.

It is hoped that the necessary studies can progressively be conducted to validate therapies for related diseases, such as Diabetic Retinopathy or Stargardt’s disease. The LIM21 and LIM109 molecules belong to a family of compounds designed in the laboratory of Dr. Juan Carlos Morales due to their neuroprotective and anti-inflammatory properties.

For this reason, the Limnopharma team plans to study the viability of some of these molecules for the treatment of pathologies in which these processes play an important role. These medium- to long-term projects are based on preliminary experiments in Huntington’s disease and Multiple Sclerosis models.

With the collaboration and support of:

New therapies for retinal diseases.
Treatments for Age-Related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP)

Headquarters

Avda. de la Innovación, 1
Edificio BIC
18016 - Granada

Links of interest

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